Scientific programme:

Scientific programme - .pdf
Poster session - .pdf

Thursday, October 22, 2015


9.00 - 9.05          Opening ceremony

9.05 - 9.45          Opening Lecture

                          Paweł Grieb (Poland) Tissue stress phenomena in the brain in the context of mechanism of neurological diseases and
  therapeutic neuroprotection

9.45 - 10.30         Plenary Lecture

                          TBC. M1 muscarinic agonists and a novel and highly potent activator of the M1R/sigma-1R complex: Future
  therapeutics of Alzheimer’s (AD) and Parkinson's Disease (PD)

10.30 - 10.45       Coffee break


10.45 - 12.50       Session 1: Novel insights in Parkinson’s disease – targets for neuroprotection

                          Chairpersons: Krystyna Ossowska and Anna R. Carta


10.45 - 11.10       Joanna Motyl (Poland) Sphingolipid signalling in experimental model of Parkinson’s disease

11.10 - 11.35       Grzegorz Kreiner (Poland) Noradrenergic signaling in Parkinson's disease

11.35 - 12.00       Klemencja Berghauzen-Maciejewska (Poland) A search for mechanisms of Parkinson’s disease (PD)-associated
  depression in an animal model

12.00 - 12.25       Anna R. Carta (Italy) PPAR-gamma: therapeutic prospects in Parkinson's disease

12.25 - 12.50       Carsten Culmsee (Germany) Regulated cell death pathways converging at mitochondria are promising therapeutic targets
  for neuroprotection

12.50 - 14.00       Lunch

14.00 - 14.30       Poster session – part I


14.30 - 16.10       Session 2: Recent advancements and future perspectives in neurodegeneration and neuroregeneration

                          Chairpersons: Barbara Zabłocka and Nadežda Lukáčová


14.30 - 14.55       Joanna Klimaszewska-Łata (Poland) Differential susceptibility of microglial cells and cholinergic neurons to
  neurodegenerative signals

14.55 - 15.20       Małgorzata Beręsewicz (Poland) PKCβII in mitochondria as a potential neuroprotective factor. Proteomics strategy to
  elucidate protein-protein interactions involved in PKC
βII signaling

15.20 - 15.45       Joanna Sypecka (Poland) Neuroprotective and immunomodulatory properties of oligodendrocyte progenitors as a tool for
  neuroregenerative strategies

15.45 - 16.10       Nadežda Lukáčová (Slovakia) Therapeutic relevance of local hypothermia after spinal cord compression: A
                          characterization of neurofilaments in white matter pathology

16.10 - 16.40       Coffee and posters – part II

Friday, October 23, 2015


9.00 - 10.30         Session 3: Emerging signalling pathways in Alzheimer’s disease –  part I

                          Chairpersons: Joanna B. Strosznajder and Anne Eckert


9.00 - 9.30           Andrzej Szutowicz (Poland) Cholinergic hypothesis of dementia

9.30 - 10.00         Grażyna Niewiadomska (Poland) Dangerous Liaisons: tau interaction with muscarinic receptors

10.00 - 10.30       Grzegorz A. Czapski (Poland) Cyclin-dependent kinase 5 signalling in neuroinflammation and neurodegeneration

10.30 - 11.00       Coffee break


11.00 - 12.30       Session 3: Emerging signalling pathways in Alzheimer’s disease –  part II

                          Chairpersons: Joanna B. Strosznajder and Anne Eckert


11.00 - 11.30       Anne Eckert (Switzerland) Neurosteroids and Alzheimer's disease. Mitochondria at the interface

11.30 - 12.00       Walter Lukiw (USA) Pathogenic microRNA (miRNA) signaling in Alzheimer’s disease (AD) and age-related macular
  degeneration (AMD) target common genetic pathways leading to amyloidogenesis and inflammatory neurodegeneration

12.00 - 12.30       Grace Sun (USA) Insights for botanical polyphenols to target signaling pathways and regulate microglial activation


12.30 - 13.30       Lunch


13.30 - 14.00       Poster session - part I



14.00 - 16.00       Session 4: Synaptic biology: New targets for therapy in Autism Spectrum Disorders

                          Chairpersons: Agata Adamczyk and David Beversdorf


14.00 - 14.30       David Beversdorf (USA) Effects and mechanisms of prenatal stress on neuro-development: applications to autism

14.30 - 15.00       Agata Adamczyk (Poland) Synaptic Shank proteins alterations in rat offspring following maternal immune activation:
  implications for autism spectrum disorders

15.00 - 15.30       Ksenia Meyza (Poland) Synaptic plasticity impairments in a BTBR T+Iptr3tf/J mouse model of idiopathic autism

15.30 - 16.00       Anna Wilkaniec (Poland) alpha-Synuclein and its role in synaptic function


16.00 - 16.30       Coffee and posters - part II


16.30                  Closing ceremony



General Guidelines for the Poster Session

And Poster Session Organization


Thursday, October 22, 2015


Poster Session Part I: 14.00 – 14.30


Elżbieta Salińska                    (Posters 1 – 6)

Grzegorz Sulkowski                (Posters 7 – 11)

Poster Session Part II: 16.10 – 16.40

Andrzej Kochański                 (Posters 12 – 17)

Magdalena Zielińska              (Posters 18 – 25)

Friday, October 23, 2015


Poster Session Part I: 13.30 – 14.00


Robert P. Strosznajder            (Posters 1 – 8)

Poster Session Part II: 16.00 – 16.30

Aleksandra Misicka-Kęsik       (Posters 9 – 16)              

Joanna Sypecka                     (Posters 17 – 23)                  


Guidelines for Poster Presenters

Poster layout

Please check if your poster has vertical or horizontal layout.


Posters 1-11 - vertical layout (maximal dimensions: 150 cm high, 90 cm wide)

Posters 12-24 - horizontal layout (maximal dimensions: 90 cm high, 145 cm wide)


Posters 1-8 - vertical layout (maximal dimensions: 150 cm high, 90 cm wide)

Posters 9-22 - horizontal layout (maximal dimensions: 90 cm high, 145 cm wide)


Poster Session Guidelines

Authors should mount their poster prior to the poster session on the assigned day, then must remain with their posters for the duration of their scheduled session (both parts!) as indicated in the programme. All posters must remain up until the session ends and then must be removed without delay. The poster sessions will be chaired and during this part of session each poster presenter will give a brief verbal presentation (max. 2 minutes). During the other part of the poster session the participants will be invited to go around the posters and discuss with the presenters.


Poster session on Thursday, October 22, 2015

From cell physiology to pathology and therapy of nervous system

1.       Neuroprotective benefits of physical activity in a chronic mouse model of Parkinson’s disease. Ewelina Pałasz, Anna Gąsiorowska,
Wiktor Niewiadomski, Grażyna Niewiadomska

2.       Neuroprotective action of 3,3’-diindolylmethane on hippocampal cells exposed to ischemia involves inhibition of caspases and p38
stress-activated protein kinase. Joanna Rzemieniec, Ewa Litwa, Agnieszka Wnuk, Małgorzata Kajta, Władysław Lasoń

3.       The effect of preconditioning with hyperbaric oxygen on brain tissue expression of proteasomal and apoptotic proteins after
experimental global brain ischemia.
Robert P. Ostrowski, Katarzyna Stępień, Emanuela Pucko, Renata Wojda, Marcin Gamdzyk, Wanda Chrzanowska, Ewa Matyja

4.       The stimulation of hippocampal neurogenesis by a histone deacetylase inhibitor- Trichostatin A, after neonatal hypoxia-ischemia.
Joanna Jaworska, Małgorzata Ziemka-Nałęcz , Teresa Zalewska

5.       Energy metabolism in neurons exposed to hypoxia-inducing chemicals Beata Gapys, Marlena Zyśk, Anna Ronowska, Hanna

6.       The role of peripheral sensory pathways and NKA1 and NKA2 receptors in cardiorespiratory effects induced by neurokinin A. Monika
Białkowska, Małgorzata Szereda-Przestaszewska, Katarzyna Kaczyńska

7.       Pathomechanism of multiple sclerosis and polymorphism of osteopontin gene. Mieczyslaw Wender, Justyna Biernacka-Lukanty,
Sławomir Michalak, Beata Raczak, Wojciech Kozubski, Dariusz Urbanski, Grażyna Michałowska-Wender

8.       Possible involvement of kinin B1 receptor in the development of experimental autoimmune encephalomyelitis in rats. Karolina
Podsiadło, Beata Dąbrowska-Bouta, Tomasz Grygorowicz, Lidia Strużyńska

9.       THE K-NN and ROC estimation of significance of some matrix metalloproteinases as markers in ALS and EDMD patients. Beata
Sokołowska, Irena M. Niebroj-Dobosz, Marta Hallay-Suszek, Agnieszka Madej-Pilarczyk, Michał Marchel, Piotr Janik, Adam Jóźwik, and Irena Hausmanowa-Petrusewicz†

10.   Changes of sFas, its ligand – sFasL and Bcl-2 in cerebrospinal fluid and serum of multiple sclerosis patients, during relapse and after glucocorticoid therapy. Wanda Gordon-Krajcer  and Krystyna Mitosek-Szewczyk

11.   Comparison between enzymatic and nephelometric serum ceruloplasmin assays in the diagnosis of Wilson’s disease. Mariola
Wolanin, Bożena Kłysz, Tomasz Litwin, Anna Członkowska

12.   Regulation of the membrane potential in the medial prefrontal cortex (mPFC) pyramidal neurons by muscarinic receptors. Przemysław N. Kurowski, Maciej Gawlak, Paweł Szulczyk

13.   Adrenergic control of membrane potential in medial prefrontal cortex (mPFC) pyramidal neurons. Katarzyna E. Grzelka, Paweł

14.   Human and bovine nuclear matrix protein complexes bind to the first intron of the tyrosine hydroxylase gene. Joanna Jabłońska, Piotr Wasąg, Anna Goc, Robert Lenartowski

15.   Genetic variants of SLC6A4, HCRTR1, KCNK18 genes in migraine patients. Marta Kowalska, Anna Oczkowska, Michał Prendecki, Magdalena Kapelusiak-Pielok, Wojciech Kozubski, Jolanta Dorszewska

16.   Impact of triclosan on CYP1A1 and CYP1B1 expression and activity in mouse neocortical neurons. Konrad A. Szychowski, Agnieszka Wnuk, Małgorzata Kajta, Anna K. Wójtowicz

17.   The effect of designer drugs on neurotransmission in the rat brain. Katarzyna Kamińska, Alexandra Jurczak, Krystyna Gołembiowska

18.   Changes of glutathione homoeostasis in rat brain during subchronic oral exposure to silver nanoparticles or silver ions. Joanna Skalska, Małgorzata Frontczak-Baniewicz, Aleksandra Lenkiewicz , Lidia Strużyńska

19.   The oxidative stress in myelin of the rat brain exposed to silver nanoparticles. Beata Dąbrowska-Bouta, Grzegorz Sulkowski, Mateusz Zięba, Jolanta Orzelska, Lidia Strużyńska

20.   Ammonia reduces intracellular  ADMA concentration in cultured astrocytes and brain endothelial cells (RBE-4) via y+LAT2-mediated efflux. Krzysztof Milewski, Jan Albrecht, Wojciech Hilgier, Magdalena Zielińska

21.   The effect of Perinatal Exposure to lead (Pb) on trafficking and scaffolding proteins dysfunction in rat brain. Magdalena Gąssowska, Irena Baranowska-Bosiacka, Joanna Moczydłowska, Lidia Strużyńska, Izabela Gutowska, Dariusz Chlubek, Agata Adamczyk

22.   The impact of di-(2-ethylhexyl) phthalate (DEHP) on PPAR-gamma, MMP-2 and MMP-9 expression in mouse astrocytes and cortical neurons in vitro. Agnieszka M. Sitarz, Konrad A. Szychowski, Anna K. Wójtowicz

23.   Apoptotic and toxic effects of benzophenone-3 (BP-3) in mouse embryonic neuronal cells. Agnieszka Wnuk, Joanna Rzemieniec, Ewa Litwa, Małgorzata Kajta

24.   Effect of telmisartan on kynurenic acid production in rat brain cortex. Izabela Zakrocka, Waldemar A. Turski, Tomasz Kocki

25.   Nanofiber mat dressing-mediated glutamate delivery to the spinal cord damages blood-brain barrier. Dorota Dziewulska, Dorota
Sulejczak, Stanisław J. Chrapusta, Anna Taraszewska, Paweł Nakielski, Małgorzata Modrzewska-Lewczuk, Lidia Wąsowska, Janina Rafałowska



Poster session on Friday, October 23, 2015

Current issues in molecular mechanism of neurodegeneration and neuroprotection

1.       Amyloid beta and its role in regulation of gene expression for APP cleaving enzymes. Implication in Alzheimer’s pathology.
Przemysław Wencel and Robert P. Strosznajder

2.       8-Oxoguanine DNA glycosylase 1 and TP53 genetic variants and apolipoprotein E (APOE) genotype and oxidative stress in the
patients with Alzheimer’s disease.
Jolanta Dorszewska, Michał Prendecki, Daria Truszczyńska, Jolanta Florczak-Wyspiańska, Urszula Łagan-Jędrzejczyk, Anna Oczkowska, Wojciech Kozubski

3.       Effect of Zn on N-acetyl-L-aspartate synthesis in SN56 neuroblastoma cells. Marlena Zyśk, Sylwia Gul-Hinc, Beata Gapys, Andrzej
Szutowicz, Hanna Bielarczyk

4.       Alteration of arginases and nitric oxide synthase in cells transfected with human wild-type beta amyloid precursor protein (βAPP).
Henryk Jęśko, Anna Wilkaniec, Magdalena Cieślik, Wojciech Hilgier, Magdalena Gąssowska, Walter J. Lukiw, Agata Adamczyk

5.       The interplay between amyloid β42 peptide, sphingosine kinase-1 and mitochondrial sirtuins in cell survival and death: implication in
Alzheimer’s Disease. Magdalena Cieślik, Grzegorz A. Czapski, Joanna B. Strosznajder

6.       Differential effect of KU55933, an inhibitor of ATM kinase, against hydrogen peroxide-, doxorubicin- and staurosporine- induced cell
damage in neuronal-like and astrocyte-like cell lines. Jakub Chwastek, Danuta Jantas, Władysław Lasoń

7.       Neuroprotective effects of necrostatin-1 against oxidative stress- and pro-apoptotic factors-induced cell damage in human
neuroblastoma SH-SY5Y cells. Danuta Jantas, Jakub Chwastek, Beata Grygier, Władysław Lasoń

8.       Alkaloids from Huperzia selago protect dopaminergic PC12 cells against sodium nitroprusside-evoked oxidative stress, mitochondrial
dysfunction and apoptosis.
Anna M. Lenkiewicz, Grzegorz A. Czapski, Anna Wilkaniec, Wojciech Szypuła, Agata Adamczyk

9.       New bifunctional peptides with both, opioid agonist and tachykinin antagonist components as new analgesics. Jolanta Dyniewicz, Piotr
Kosson, Piotr Lipiński, Aleksandra Misicka-Kęsik, Andrzej W. Lipkowski

10.   The study of influence of minocycline on Botulinum toxin A on pro- and antinociceptive interleukins under neuropathic pain. Ewelina Rojewska, Magdalena Zychowska, Wioletta Makuch, Sara Marinelli, Siro Luvisetto, Flaminia Pavone, Barbara Przewłocka, Joanna Mika

11.   Effects of microglial cell polarization on nociception and morphine-analgesia – in vivo and in vitro studies. Katarzyna Popiołek-Barczyk, Anna Piotrowska, Natalia Kołosowska, Ewelina Rojewska, Wioletta Makuch, Dominika Piłat, Agnieszka Jurga, Joanna Mika

12.   Opioid agonist-neurokinin 1 antagonist designed multiple ligands alleviate both acute and neuropathic pain in rats. Joanna Starnowska, Wioletta Makuch, Cecilia Betti, Łukasz Frankiewicz, Alexandre Novoa, Dirk Tourwé, Steven Ballet, Joanna Mika, Barbara Przewłocka

13.   Carbon monoxide-releasing molecule (CORM-2) deflates neuropathic pain symptoms and potentiates opioid effectiveness in rat CCI
Agnieszka M. Jurga, Anna Piotrowska, Joanna Starnowska, Ewelina Rojewska, Wioletta Makuch, Joanna Mika

14.   Minocycline enhance botulinum neurotoxin A analgesia under neuropathic pain via glia modulation. Wioletta Makuch, Ewelina
Rojewska, Magdalena Zychowska, Sara Marinelli, Siro Luvisetto, Flaminia Pavone, Barbara Przewlocka, Joanna Mika

15.   Participation of pro- and antinociceptive interleukins in maraviroc analgesia in rat neuropathic pain model. Anna Piotrowska, Klaudia
Kwiatkowski, Ewelina Rojewska, Wioletta Makuch, Joanna Mika

16.   Cardiorespiratory activity of PK20, a potent anti-inflammatory and antinociceptive hybrid peptide. Piotr Wojciechowski, Patrycja
Kleczkowska, Katarzyna Kaczyńska

17.   Monitoring of human mesenchymal stem cells overexpressing VLA-4 after their intracarotid administration in a rat model of deep brain structure damage. Anna Andrzejewska, Sylwia Koniusz, Adam Nowakowski, Mirosław Janowski, Barbara Łukomska

18.   Alternative methods for staining and characterization of extracellular vesicles derived from human bone marrow mesenchymal stromal cells. Sylwia Koniusz, Andrea Del Fattore, Małgorzata Frontczak-Baniewicz, Maurizio Muraca, Barbara Łukomska

19.   The phenotypic characterization and therapeutic application of human mesenchymal stem cells derived from adipose tissue. Anna
Figiel-Dąbrowska, Patrycja Siedlecka, Krystyna Domańska-Janik, Anna Sarnowska

20.   Influence of isolation and cultivation methods on stemness properties of human Wharton's Jelly-derived MSC population. Wioletta Lech, Katarzyna Drela, Anna Sarnowska, Krystyna Domańska-Janik

21.   The influence of 3D microenvironment and oxygen tension on WJ-MSC and HUCB-NSC fate decisions. Martyna Podobińska, Michał
Piątek, Krystyna Pietrucha, Ashok Kumar, Anna Sarnowska, Leonora Bużańska

22.   Treatment of neural stem cells (HUCB-NSC) with methylmercure chloride results with cytotoxic and genotoxic effect. Justyna
Augustyniak, Marzena Zychowicz, Martyna Podobińska, Leonora Bużańska

23.   Vasculoprotective effect of WJ-derived MSC and EPC-like culture on post-ischemic organotypic hippocampal slices. Patrycja
Siedlecka, Anna Sarnowska, Lukasz Strojek, Krystyna Domanska-Janik